Experimental evaluation of second-line oral treatments of visceral leishmaniasis caused by Leishmania infantum.
نویسندگان
چکیده
In a murine model of Leishmania infantum visceral leishmaniasis, metronidazole, ketoconazole, fluconazole, itraconazole, and terbinafine were less effective than antimonial agents in reducing hepatic parasite load. Ketoconazole potentiated the effect of meglumine antimoniate reference therapy through its marked activity against spleen infection.
منابع مشابه
Generation of Luciferase-Expressing Leishmania infantum chagasi and Assessment of Miltefosine Efficacy in Infected Hamsters through Bioimaging
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 43 1 شماره
صفحات -
تاریخ انتشار 1999